HERE'S THE LINK 'CAUSE THE ADS COVER THE DAMN PIC

on the left, i made a red border around my most prized posession, my "pics" folder. It has all my pics that i keep, music, photoshop brushes, graphic textures, etc. That I don't wish to delete.
But the rest of the space is programs and probably pointless crap that might be on the right side. Is there ANYTHING on here that shouldn't be? is there any folders i can safely delete? (like in the windows, system, programs areas)
i'm concerned because i have a total of 8GB of space. with an 880MB PhotoShop temp file running, and a 2.2GB "pics" folder size, i only have 700-somethingMB of space left. Usually I have about 1GB of free space. but the past few weeks it's lowered. I don't wanna get to 200MB. because PhotoShop won't work. that programs is special to me.
is there something there that's not supposed to be? i really wanna free more space. WITHOUT deleting anything from my pics folder.
i really need help. thanks :D
btw, i run disk cleanup, CCleaner, DustBusterXP, etc on a daily basis...so i don't know what the hell is taking up all this space.